Nuclear factor-kappa B and its role in inflammatory lung disease.

Alharbi KS, Fuloria NK, Fuloria S, Rahman SB, Al-Malki WH, Javed Shaikh MA, Thangavelu L, Singh SK, Rama Raju VS, Jha NK, Chellappan DK, Dua K, Gupta G

Chem Biol Interact - (-) 109568 [2021-06-25; online 2021-06-25]

Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, COPD, bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-κB, which is a member of the Rel protein family. Five members of this family c-REL, NF-κB2 (p100/p52), RelA (p65), NF-κB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-κB activation. NF-κB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-κB a key target for drug production.

Type: Review

PubMed 34181887

DOI 10.1016/j.cbi.2021.109568

Crossref 10.1016/j.cbi.2021.109568

pii: S0009-2797(21)00206-4

Publications 9.5.0