Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons.

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Eidhof I, Twohig D, Falk A

Cell Stem Cell 31 (2) 152-154 [2024-02-01; online 2024-02-03]

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.

Category: Health

Type: Preprint

PubMed 38306990

DOI 10.1016/j.stem.2024.01.002

Crossref 10.1016/j.stem.2024.01.002

pii: S1934-5909(24)00002-X