3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort.

Kim J, Jeon J, Jang H, Moon Y, Abafogi AT, van Noort D, Lee J, Kang T, Park S

Nano Converg 10 (1) 45 [2023-09-16; online 2023-09-16]

The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 ┬ÁL of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.

Category: Health

Type: Journal article

PubMed 37715925

DOI 10.1186/s40580-023-00393-3

Crossref 10.1186/s40580-023-00393-3

pmc: PMC10505115
pii: 10.1186/s40580-023-00393-3

Publications 9.5.0