Power and sample size calculation for the win odds test: application to an ordinal endpoint in COVID-19 trials.

Gasparyan SB, Kowalewski EK, Folkvaljon F, Bengtsson O, Buenconsejo J, Adler J, Koch GG

J Biopharm Stat - (-) 1-23 [2021-09-23; online 2021-09-23]

The win odds is a distribution-free method of comparing locations of distributions of two independent random variables. Introduced as a method for analyzing hierarchical composite endpoints, it is well suited to be used in the analysis of ordinal scale endpoints in COVID-19 clinical trials. For a single outcome, we provide power and sample size calculation formulas for the win odds test. We also provide an implementation of the win odds analysis method for a single ordinal outcome in a commonly used statistical software to make the win odds analysis fully reproducible.

Category: Other

Type: Journal article

PubMed 34551682

DOI 10.1080/10543406.2021.1968893

Crossref 10.1080/10543406.2021.1968893

Publications 9.5.0