Autoantibodies and infection with SARS-CoV2 infection: The spectrum from association to clinical implicationreport of the 15th Dresden symposium on autoantibodies.
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Damoiseaux J, Dotan A, Fritzler MJ, Bogdanos DP, Meroni PL, Roggenbuck D, Goldman M, Landegren N, Bastard P, Shoenfeld Y, Conrad K
Autoimmun Rev - (-) 103012 [2021-12-09; online 2021-12-09]
The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.
PubMed 34896650
DOI 10.1016/j.autrev.2021.103012
Crossref 10.1016/j.autrev.2021.103012
pii: S1568-9972(21)00294-9
pmc: PMC8656211