Risk factors for mortality in adult COVID-19 patients; frailty predicts fatal outcome in older patients.
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Tehrani S, Killander A, Åstrand P, Jakobsson J, Gille-Johnson P
Int J Infect Dis - (-) - [2020-10-29; online 2020-10-29]
This study investigated demographics, co-morbidities and death rate in hospitalized patients with confirmed COVID-19. In addition, we hypothesized that functional status, according to Clinical Frailty Scale (CFS), in patients aged 65 years and older is a better predictor of poor outcome than age and co-morbidities. A total of 255 randomly selected COVID-19 patients admitted at a university hospital were included and followed for 60 days. Patient data was extracted manually from the electronic health records using a standardized protocol. The age of the study population ranged between 20 and 103 years, (mean age was 66±17 years). Hypertension, diabetes mellitus and obesity were the three most prevalent co-morbidities. At the 60-day follow-up, 70 patients (27%) had died. In multivariate analyses, age, chronic kidney disease and previous stroke were associated with death. Most fatal cases (90%) occurred in older patients. Among the older patients, CFS was the only predictor of death in multivariate analyses. This study shows that higher age, chronic kidney disease and previous stroke significantly contribute to a fatal outcome in hospitalized patients with COVID-19. In patients aged 65 years and older, CFS was the strongest prognostic factor for mortality.
Category: Social Science & Humanities
PubMed 33130213
DOI 10.1016/j.ijid.2020.10.071
Crossref 10.1016/j.ijid.2020.10.071
pii: S1201-9712(20)32276-1