Effectiveness of the XBB.1.5 COVID-19 Vaccines Against SARS-CoV-2 Hospitalisation Among Adults Aged ≥ 65 Years During the BA.2.86/JN.1 Predominant Period, VEBIS Hospital Study, Europe, November 2023 to May 2024.
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Antunes L, Rojas-Castro M, Lozano M, Martínez-Baz I, Leroux-Roels I, Borg ML, Oroszi B, Fitzgerald M, Dürrwald R, Jancoriene L, Machado A, Petrović G, Lazar M, Součková L, Bacci S, Howard J, Verdasca N, Basile L, Castilla J, Ternest S, Džiugytė A, Túri G, Duffy R, Hackmann C, Kuliese M, Gomez V, Makarić ZL, Marin A, Husa P, Nicolay N, Rose AMC, VEBIS SARI VE network team
Influenza Other Respir Viruses 19 (3) e70081 [2025-03-00; online 2025-03-10]
We estimated the effectiveness of the adapted monovalent XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation during the BA.2.86/JN.1 lineage-predominant period using a multicentre test-negative case-control study in Europe. We included older adults (≥ 65 years) hospitalised with severe acute respiratory infection from November 2023 to May 2024. Vaccine effectiveness was 46% at 14-59 days and 34% at 60-119 days, with no effect thereafter. The XBB.1.5 COVID-19 vaccines conferred protection against BA.2.86 lineage hospitalisation in the first 4 months post-vaccination.
PubMed 40059069
DOI 10.1111/irv.70081
Crossref 10.1111/irv.70081