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Budich JC, Bergholtz EJ
Math Med Biol - (-) - [2021-10-25; online 2021-10-25]
Containment, aiming to prevent the epidemic stage of community-spreading altogether, and mitigation, aiming to merely 'flatten the curve' of a wide-ranged outbreak, constitute two qualitatively different approaches to combating an epidemic through non-pharmaceutical interventions. Here, we study a simple model of epidemic dynamics separating the population into two groups, namely a low-risk group and a high-risk group, for which different strategies are pursued. Due to synchronization effects, we find that maintaining a slower epidemic growth behaviour for the high-risk group is unstable against any finite coupling between the two groups. More precisely, the density of infected individuals in the two groups qualitatively evolves very similarly, apart from a small time delay and an overall scaling factor quantifying the coupling between the groups. Hence, selective containment of the epidemic in a targeted (high-risk) group is practically impossible whenever the surrounding society implements a mitigated community-spreading. We relate our general findings to the ongoing COVID-19 pandemic.
PubMed 34695187
DOI 10.1093/imammb/dqab013
Crossref 10.1093/imammb/dqab013
pii: 6409757