Comorbidity status of deceased COVID-19 in-patients in Italy.

Vetrano DL, Tazzeo C, Palmieri L, Marengoni A, Zucchelli A, Lo Noce C, Onder G, Italian National Institute of Health Covid-Mortality Group

Aging Clin Exp Res 33 (8) 2361-2365 [2021-08-00; online 2021-06-24]

Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated. A random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values ≥ 1.5. Six pairs of diseases exhibited O/E values ≥ 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity. In those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.

Category: Public Health

Type: Journal article

PubMed 34169447

DOI 10.1007/s40520-021-01914-y

Crossref 10.1007/s40520-021-01914-y

pmc: PMC8224257
pii: 10.1007/s40520-021-01914-y

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