Iatrogenic immunosuppression can lead to prolonged viral shedding and absent immune response to COVID-19.
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Psaros Einberg A, Casswall T, Arnell H, Nowak G, Mirazimi A, Sundin M, Fischler B
Acta Paediatr - (-) - [2021-05-27; online 2021-05-27]
In the era of the COVID-19 pandemic, paediatricians need to remember that immunocompromised children might experience prolonged viral shedding and impaired immunological response to SARS-CoV-2. We report a girl diagnosed with an unresectable angiosarcoma of the liver who underwent liver transplantation in June 2019. The basic immunosuppression protocol consisted of tacrolimus and prednisolone. Additionally, she was on adjuvant treatment with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.
PubMed 34043855
DOI 10.1111/apa.15955
Crossref 10.1111/apa.15955