The characterization of CD8+ T-cell responses in COVID-19.

Yang Y, Miller H, Byazrova MG, Cndotti F, Benlagha K, Camara NOS, Shi J, Forsman H, Lee P, Yang L, Filatov A, Zhai Z, Liu C

Emerg Microbes Infect 13 (1) 2287118 [2024-01-11; online 2024-01-11]

This review gives an overview of the protective role of CD8+ T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by CD8+ T cells in unexposed cohorts are described. Additionally, the relevance of resident CD8+ T cells in the upper and lower airway during infection and CD8+ T-cell responses following vaccination are discussed, including recent worrisome breakthrough infections and variants of concerns (VOCs). Lastly, we explain the correlation between CD8+ T cells and COVID-19 severity. This review aids in a deeper comprehension of the association between CD8+ T cells and SARS-CoV-2 and broadens a vision for future exploration.

Category: Biochemistry

Category: Health

PubMed 37990907

DOI 10.1080/22221751.2023.2287118

Crossref 10.1080/22221751.2023.2287118

pmc: PMC10786432

Publications 9.5.0