SARS-COV-2 a trigger of myelin oligodendrocyte glycoprotein-associated disorder.

Johnsson M, Asztely F, Hejnebo S, Axelsson M, Malmeström C, Olausson T, Lycke J

Ann Clin Transl Neurol 9 (8) 1296-1301 [2022-08-00; online 2022-06-17]

SARS-COV-2 frequently cause neurological disorders and is sometimes associated with onset of autoimmune diseases affecting the nervous system. Over recent years, a rare but distinct diagnosis designated myelin oligodendrocyte glycoprotein-associated disorder (MOGAD) has been recognized in patients with attacks of optic neuritis, myelitis, or encephalomyelitis and increased levels of anti-MOG antibodies. The cause of MOGAD is unknown. However, there have been reports of single cases of MOGAD in patients with Covid-19 infection. We report a series of SARS-CoV-2 positive patients that developed MOGAD, but a homology search did not support a cross-reactive immune response to SARS-CoV-2 spike-protein and MOG.

Category: Biochemistry

Category: Health

Type: Journal article

PubMed 35713508

DOI 10.1002/acn3.51609

Crossref 10.1002/acn3.51609

pmc: PMC9349599

Publications 9.5.0