The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.
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Siripanthong B, Asatryan B, Hanff TC, Chatha SR, Khanji MY, Ricci F, Muser D, Ferrari VA, Nazarian S, Santangeli P, Deo R, Cooper LT, Mohiddin SA, Chahal CAA
JACC Basic Transl Sci - (-) - [2022-02-09; online 2022-02-09]
The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
PubMed 35165665
DOI 10.1016/j.jacbts.2021.10.011
Crossref 10.1016/j.jacbts.2021.10.011
pii: S2452-302X(21)00318-1
pmc: PMC8828362