Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid.
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Lindqvist I, Cunningham JL, Mulder J, Feresiadou A, Rostami E, Virhammar J, Kumlien E
Eur J Neurol 30 (10) 3142-3148 [2023-10-00; online 2023-07-13]
COVID-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, are decsribed. Analysis of cerebrospinal fluid from the cases using indirect immunohistochemistry. Antibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus. Our results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID-19 associated myoclonus.
PubMed 37392418
DOI 10.1111/ene.15958
Crossref 10.1111/ene.15958