Shedding of infectious SARS-CoV-2 from airways in hospitalized COVID-19 patients in relation to serum antibody responses

Glans H, Gredmark-Russ S, Olausson M, Falck-Jones S, Varnaite R, Christ W, Maleki KT, Lind Karlberg M, Broddesson S, Falck-Jones R, Bell M, Johansson N, Farnert A, Smed Sorensen A, Klingstrom J, Brave A

Infect Dis . 2020 Dec 10;20(1):942. 21 (1) 494 [2020-09-13; online 2020-09-13]

To understand the risk of transmission of SARS-CoV-2 in hospitalized COVID-19 patients we simultaneously assessed the presence of SARS-CoV-2 RNA, live infectious virus in the airways, and virus-specific IgG and neutralizing antibodies in sera in 36 hospitalized COVID-19 patients. SARS-CoV-2 could be cultured from four patients, all with low or undetectable antibody response. Our data suggests that the level of SARS-CoV-2 antibodies may correlate to risk for shedding live SARS-CoV-2 virus in hospitalized COVID-19 patients.

Category: Genomics & transcriptomics

Category: Health

Funder: Hjärt-Lungfonden

Funder: VR

Type: Journal article

PubMed 34044758

DOI 10.1186/s12879-021-06202-8

Crossref 10.1186/s12879-021-06202-8

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