The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus.

Tomić D, Davidović D, Szasz AM, Rezeli M, Pirkić B, Petrik J, Vrca VB, Janđel V, Lipić T, Skala K, Mesarić J, Periša MM, Šojat Z, Rogina BM

Inform Med Unlocked 23 (-) 100529 [2021-01-30; online 2021-01-30]

Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease. Because of that we analyzed the inhibition of SARS-CoV-2 spike glycoprotein with FDA-approved antiviral drugs and their double and triple combinations. We used the Vini in silico model of cancer to perform this virtual drug screening, showing HIV drugs to be the most effective. Besides, the combination of cobicistat-abacavir-rilpivirine HIV drugs demonstrated the highest in silico efficacy of inhibiting SARS-CoV-2 spike glycoprotein. Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted.

Category: Biochemistry

Category: Drug Discovery

Type: Journal article

PubMed 33553571

DOI 10.1016/j.imu.2021.100529

Crossref 10.1016/j.imu.2021.100529

pii: S2352-9148(21)00019-8
pmc: PMC7847290
Results of the efficacy of FDA approved antiviral drugs on SARS-CoV-2 spike glycoprotein
The Vini in silico model of cancer

Publications 9.5.0