Category: Drug Discovery

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Year 2024

PubMed DOI Crossref
Tocilizumab reduces hypercoagulation in COVID-19 - Perspectives from the coagulation and immunomodulation Covid assessment (Coag-ImmCovA) clinical trial.
Almskog LM, Sjöström A, Sundén-Cullberg J, ..., Lampa J, Magnusson M
Thromb Res 243 (-) 109135 [2024-11-00; online 2024-08-30]
Category: Drug Discovery Category: Serology Type: Journal article
PubMed DOI Crossref
Sodium-glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials.
Vale C, Godolphin PJ, Fisher D, ..., Shankar-Hari M, WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group
Lancet Diabetes Endocrinol 12 (10) 735-747 [2024-10-00; online 2024-09-06]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Advances in the design and delivery of RNA vaccines for infectious diseases.
Lokras AG, Bobak TR, Baghel SS, Sebastiani F, Foged C
Adv Drug Deliv Rev 213 (-) 115419 [2024-10-00; online 2024-08-05]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Metal-Organic Frameworks: Unconventional Nanoweapons against COVID.
Álvarez-Miguel I, Fodor B, López GG, ..., Hidalgo T, Horcajada P
ACS Appl Mater Interfaces 16 (25) 32118-32127 [2024-06-26; online 2024-06-11]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Colchicine for the treatment of patients with COVID-19: an updated systematic review and meta-analysis of randomised controlled trials.
Cheema HA, Jafar U, Shahid A, ..., Sah R, Lee KY
BMJ Open 14 (4) e074373 [2024-04-17; online 2024-04-17]
Category: Drug Discovery Category: Health Category: Other Type: Review
PubMed DOI Crossref
The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses.
Bigotti MG, Klein K, Gan ES, ..., Brancaccio A, Yamauchi Y
Antiviral Res 224 (-) 105837 [2024-02-20; online 2024-02-20]
Category: Drug Discovery Category: Other Funder: VR Type: Journal article
PubMed DOI Crossref
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome.
Bogacheva MS, Kuivanen S, Potdar S, ..., Pietiäinen V, Vapalahti O
Antiviral Res 223 (-) 105813 [2024-01-24; online 2024-01-24]
Category: Drug Discovery Funder: H2020 Type: Journal article
PubMed DOI Crossref
Identifying novel inhibitors targeting Exportin-1 for the potential treatment of COVID-19.
Sharma T, Mondal T, Khan S, ..., Baig MH, Dong J
Arch Microbiol 206 (2) 69 [2024-01-19; online 2024-01-19]
Category: Drug Discovery Category: Genomics & transcriptomics Category: Proteins Funder: VR Type: Journal article
PubMed DOI Crossref
Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies.
Altincekic N, Jores N, Löhr F, ..., Sreeramulu S, Schwalbe H
ACS Chem Biol - (-) - [2024-01-17; online 2024-01-17]
Category: Drug Discovery Category: Proteins Funder: H2020 Funder: KAW/SciLifeLab National COVID program Type: Journal article

Year 2023

PubMed DOI Crossref
Polymethoxyflavone from Citrus depressa as an inhibitor against various variants of SARS-CoV-2 spike protein.
Liu T, Hsu S, Hsieh YSY, Liu H, Lee C
J Ethnopharmacol 320 (-) 117412 [2023-11-21; online 2023-11-21]
Category: Biochemistry Category: Drug Discovery Category: Proteins Type: Journal article
PubMed DOI Crossref
A community effort in SARS-CoV-2 drug discovery.
Schimunek J, Seidl P, Elez K, ..., Klambauer G, Hermans TM
Mol Inform - (-) - [2023-10-13; online 2023-10-13]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Identification of essential genes associated with SARS-CoV-2 infection as potential drug target candidates with machine learning algorithms.
Taheri G, Habibi M
Sci Rep 13 (1) 15141 [2023-09-13; online 2023-09-13]
Category: Drug Discovery Category: Genomics & transcriptomics Category: Other Type: Journal article
PubMed DOI Crossref
Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project).
Petersen JJ, Jørgensen CK, Faltermeier P, ..., Gluud C, Jakobsen JC
BMJ Open 13 (6) e064498 [2023-06-20; online 2023-06-20]
Category: Drug Discovery Category: Health Funder: VR Type: Journal article
PubMed DOI Crossref
Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies: a report from the EPICOVIDEHA registry.
Salmanton-García J, Marchesi F, Gomes da Silva M, ..., Cornely OA, EPICOVIDEHA registry
EClinicalMedicine 58 (-) 101939 [2023-04-00; online 2023-04-06]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19).
Brodin D, Tornhammar P, Ueda P, ..., Blennow O, Andersson DP
BMJ Open 13 (2) e064374 [2023-02-22; online 2023-02-22]
Category: Drug Discovery Category: Health Type: Journal article

Year 2022

PubMed DOI Crossref
No effect of remdesivir or betamethasone on upper respiratory tract SARS-CoV-2 RNA kinetics in hospitalised COVID-19 patients: a retrospective observational study.
Sourander B, Andersson L, Brink M, ..., Robertson J, Gisslén M
Infect Dis (Lond) 54 (10) 703-712 [2022-10-00; online 2022-06-16]
Category: Biochemistry Category: Drug Discovery Category: Health Funder: KAW/SciLifeLab National COVID program Research Area: Biobanks for COVID-19 research Type: Journal article
PubMed DOI Crossref
Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody Reactivity.
Samuelsson E, Mirgorodskaya E, Nyström K, ..., Liljeqvist JÅ, Nordén R
ACS Infect Dis 8 (9) 1883-1893 [2022-09-09; online 2022-08-18]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial.
Gasparyan SB, Buenconsejo J, Kowalewski EK, ..., Berwanger O, Kosiborod MN
Ther Innov Regul Sci 56 (5) 785-794 [2022-09-00; online 2022-06-14]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukaemia and small lymphocytic lymphoma (SEQUOIA): a randomised, controlled, phase 3 trial.
Tam CS, Brown JR, Kahl BS, ..., Robak T, Hillmen P
Lancet Oncol 23 (8) 1031-1043 [2022-08-00; online 2022-07-07]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
A rapid assessment of take-home naloxone provision during COVID-19 in Europe.
McDonald R, Eide D, Abel-Ollo K, ..., Thiesen H, Strang J
Int J Drug Policy 107 (-) 103787 [2022-07-01; online 2022-07-01]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial.
Coenen M, Bingel U, Zunhammer M, ..., Schedlowski M, Coch C
Trials 23 (1) 488 [2022-06-13; online 2022-06-13]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial.
Upton CM, van Wijk RC, Mockeliunas L, ..., Diacon AH, BCG CORONA Consortium
EClinicalMedicine 48 (-) 101414 [2022-06-00; online 2022-05-12]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
The chimera of S1 and N proteins of SARS-CoV-2: can it be a potential vaccine candidate for COVID-19?
Kumar A, Ladha A, Choudhury A, ..., Palit P, Tiwari ON
Expert Rev Vaccines - (-) 1-16 [2022-05-31; online 2022-05-31]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, ..., Skidmore MA, Turnbull JE
ACS Cent Sci 8 (5) 527-545 [2022-05-25; online 2022-03-29]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study.
Chhetri B, Bhagat VM, Vamsi DKK, ..., Deshmukh P, Sanjeevi CB
Acta Biotheor 70 (2) 16 [2022-05-19; online 2022-05-19]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Association between pharmaceutical modulation of oestrogen in postmenopausal women in Sweden and death due to COVID-19: a cohort study.
Sund M, Fonseca-Rodríguez O, Josefsson A, Welen K, Fors Connolly AM
BMJ Open 12 (2) e053032 [2022-02-14; online 2022-02-14]
Category: Drug Discovery Category: Health Topics: Register-based research Type: Journal article
PubMed DOI Crossref
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
Luttens A, Gullberg H, Abdurakhmanov E, ..., Danielson UH, Carlsson J
J Am Chem Soc - (-) - [2022-02-10; online 2022-02-10]
Category: Biochemistry Category: Drug Discovery Category: Health Funder: KAW/SciLifeLab National COVID program Research Area: Drug discovery and repurposing of drugs Research Area: Pandemic preparedness Type: Journal article
PubMed DOI Crossref
Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May be Mediated by Dehydroepiandrosterone.
Papadopoulos KI, Papadopoulou A, Sutheesophon W, Aw TC
J Urol - (-) 101097JU0000000000002469 [2022-02-04; online 2022-02-04]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.
Sanchez-Burgos L, Gómez-López G, Al-Shahrour F, Fernandez-Capetillo O
Sci Rep 12 (1) 1626 [2022-01-31; online 2022-01-31]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Humoral immunogenicity and tolerability of heterologous ChAd/BNT compared with homologous BNT/BNT and ChAd/ChAd SARS-CoV-2 vaccination in hemodialysis patients : A multicenter prospective observational study.
Haase M, Lesny P, Anderson M, ..., Veiga PM, Macario F
J Nephrol - (-) - [2022-01-27; online 2022-01-27]
Category: Drug Discovery Category: Health Category: Other Type: Journal article
DOI Crossref
Novel universal SARS-CoV DNA vaccine inducing neutralizing antibodies to huCoV-19/WH01, Beta, Delta and Omicron variants and T cells to Bat-CoV
Appelberg KS, Ahlen G, Nikoyan N, ..., mirazimi a, Sallberg M
Research Square - (-) - [2022-01-20; online 2022-01-20]
Category: Biochemistry Category: Drug Discovery Category: Health Category: Omicron VoC Category: Vaccines Type: Preprint
PubMed DOI Crossref
Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.
Schjesvold FH, Dimopoulos MA, Delimpasi S, ..., Sonneveld P, OCEAN (OP-103) Investigators
Lancet Haematol - (-) - [2022-01-12; online 2022-01-12]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Preclinical evaluation of [11C]GW457427 as a tracer for neutrophil elastase.
Estrada S, Elgland M, Selvaraju RK, ..., Nordeman P, Antoni G
Nucl Med Biol 106-107 (-) 62-71 [2022-01-11; online 2022-01-11]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Repurposing of Medicines in the EU: Launch of a Pilot Framework.
Asker-Hagelberg C, Boran T, Bouygues C, ..., Penninckx W, Stepniewska B
Front Med (Lausanne) 8 (-) 817663 [2022-01-10; online 2022-01-10]
Category: Drug Discovery Category: Health Type: Journal article

Year 2021

PubMed DOI Crossref
Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo.
Cui L, Hunter MR, Sonzini S, ..., Mahmoudi N, Desai AS
Small - (-) e2105832 [2021-12-16; online 2021-12-16]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
The profile of the COvid-19 VACcination register SAFEty study in Sweden (CoVacSafe-SE).
Ljung R, Sundström A, Grünewald M, ..., Gedeborg R, Zethelius B
Ups J Med Sci 126 (-) - [2021-12-10; online 2021-12-10]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Rituximab Infusion Timing, Cumulative Dose, and Hospitalization for COVID-19 in Persons With Multiple Sclerosis in Sweden.
McKay KA, Piehl F, Englund S, ..., Hillert J, Frisell T
JAMA Netw Open 4 (12) e2136697 [2021-12-01; online 2021-12-01]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA.
Rich C, Eriksson D, Dolfi F, ..., Dabbous F, Nazir J
Clin Exp Immunol - (-) - [2021-11-27; online 2021-11-27]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease.
Alalam H, Sigurdardóttir S, Bourgard C, ..., Grøtli M, Sunnerhagen P
mSystems - (-) e0108721 [2021-11-23; online 2021-11-23]
Category: Biochemistry Category: Drug Discovery Category: Health Funder: VR Type: Journal article
PubMed DOI Crossref
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
Kruse T, Benz C, Garvanska DH, ..., Nilsson J, Ivarsson Y
Nat Commun 12 (1) 6761 [2021-11-19; online 2021-11-19]
Category: Biochemistry Category: Drug Discovery Category: Health Funder: KAW/SciLifeLab National COVID program Research Area: Host cell systems biology and targets Type: Journal article
PubMed DOI Crossref
COVID-19 vaccination in autoimmune disease (COVAD) survey protocol.
Sen P, Gupta L, Lilleker JB, ..., Aggarwal R, COVAD Study Group
Rheumatol Int - (-) - [2021-11-15; online 2021-11-15]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial.
Granholm A, Munch MW, Myatra SN, ..., Lange T, Perner A
Intensive Care Med - (-) - [2021-11-10; online 2021-11-10]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Antibody response to COVID-19 mRNA vaccine (Comirnaty) in myeloma patients treated with high-dose melphalan and/or immunotherapy.
Lockmer S, Uttervall K, Kashif M, ..., Lund J, Nahi H
Am J Hematol 96 (11) E443-E446 [2021-11-01; online 2021-09-22]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia: The COVID STEROID randomised, placebo-controlled trial.
Munch MW, Meyhoff TS, Helleberg M, ..., Lange T, Perner A
Acta Anaesthesiol Scand 65 (10) 1421-1430 [2021-11-00; online 2021-09-20]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database.
Jung SY, Kim MS, Li H, ..., Shin JI, Smith L
Clin Transl Sci - (-) - [2021-10-31; online 2021-10-31]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Comparative safety of mRNA COVID-19 vaccines to influenza vaccines: A pharmacovigilance analysis using WHO international database.
Kim MS, Jung SY, Ahn JG, ..., Il Shin J, Smith L
J Med Virol - (-) - [2021-10-28; online 2021-10-28]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults
Lanini S, Capone S, Antinori A, ..., Zamboni D, Mazzaferri F
Sci. Transl. Med. - (-) - [2021-10-26; online 2021-10-26]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.
Schultheiß C, Paschold L, Willscher E, ..., Gagliani N, Binder M
iScience - (-) 103325 [2021-10-23; online 2021-10-23]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Clozapine treatment and risk of severe COVID-19 infection.
Ohlis A, Sörberg Wallin A, Sarafis A, ..., Ahlen J, Dalman C
Acta Psychiatr Scand - (-) - [2021-10-22; online 2021-10-22]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Immunogenicity and safety of AZD1222 (ChAdOx1 nCoV-19) against SARS-CoV-2 in Japan: A double-blind, randomized controlled phase 1/2 trial.
Asano M, Okada H, Itoh Y, ..., Olsson U, Vekemans J
Int J Infect Dis - (-) - [2021-10-21; online 2021-10-21]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial.
COVID STEROID 2 Trial Group , Munch MW, Myatra SN, ..., Venkatesh B, Perner A
JAMA - (-) - [2021-10-21; online 2021-10-21]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients.
Melin J, Svensson MK, Albinsson B, Winqvist O, Pauksens K
BMC Immunol 22 (1) 70 [2021-10-19; online 2021-10-19]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19.
Rivero-García I, Castresana-Aguirre M, Guglielmo L, Guala D, Sonnhammer ELL
Sci Rep 11 (1) 20687 [2021-10-19; online 2021-10-19]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies.
Cao Y, Choi YK, Frank M, ..., Seok C, Im W
J Chem Theory Comput 17 (10) 6559-6569 [2021-10-12; online 2021-09-16]
Category: Drug Discovery Category: Health Category: Proteins Type: Journal article
PubMed DOI Crossref
Time-dependent evolution of IgG antibody levels after first and second dose of mRNA-based SARS-CoV-2 vaccination in hemodialysis patients: a multicenter study.
Santos-Araújo C, Veiga PM, Santos MJ, ..., Haase M, Macário F
Nephrol Dial Transplant - (-) - [2021-10-11; online 2021-10-11]
Category: Drug Discovery Category: Health Type: Journal article
DOI Crossref
Global Prevalence of Adaptive and Prolonged Infections’ Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein
Lennerstrand J, Palanisamy N
Viruses 13 (10) 1974 [2021-09-30; online 2021-09-30]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
High level of protection against COVID-19 after two doses of BNT162b2 vaccine in the working age population – first results from a cohort study in Southern Sweden
Björk J, Inghammar M, Moghaddassi M, ..., Malmqvist U, Kahn F
Infect Dis (Lond) - (-) 1-6 [2021-09-29; online 2021-09-29]
Category: Biochemistry Category: Drug Discovery Category: Health Category: Vaccines Funder: VR Type: Journal article
DOI Crossref
A Retrospective Cross-Sectional Study Assessing Self-Reported Adverse Events following Immunization (AEFI) of the COVID-19 Vaccine in Bangladesh
Sultana A, Shahriar S, Tahsin MR, ..., Hossain MA, Amran MS
Vaccines 9 (10) 1090 [2021-09-28; online 2021-09-28]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach
Kesarwani V, Gupta R, Vetukuri RR, Kushwaha SK, Gandhi S
Front Immunol 12 (-) - [2021-09-24; online 2021-09-24]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination.
van de Munckhof A, Krzywicka K, Aguiar de Sousa D, ..., Ferro JM, Coutinho JM
Eur J Neurol - (-) - [2021-09-18; online 2021-09-18]
Category: Drug Discovery Category: Health Category: Vaccines Type: Journal article
PubMed DOI Crossref
Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination
Normark J, Vikström L, Gwon YD, ..., Ahlm C, Forsell M
N Engl J Med 385 (11) 1049-1051 [2021-09-09; online 2021-09-09]
Category: Biochemistry Category: Drug Discovery Category: Vaccines Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Vaccine Type: Journal article
PubMed DOI Crossref
Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19.
Yin Y, Su W, Zhang J, ..., Nie G, Wang H
ACS Nano - (-) - [2021-09-02; online 2021-09-02]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Vaccine effectiveness against infection with the Delta (B.1.617.2) variant, Norway, April to August 2021.
Seppälä E, Veneti L, Starrfelt J, ..., Watle SV, Meijerink H
Euro Surveill 26 (35) - [2021-09-00; online 2021-09-04]
Category: Drug Discovery Category: Genomics & transcriptomics Category: Vaccines Type: Journal article
PubMed DOI Crossref
The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses.
Calistri A, Luganini A, Mognetti B, ..., Gribaudo G, Parolin C
Microorganisms 9 (8) 1731 [2021-08-14; online 2021-08-14]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
A phenomics approach for antiviral drug discovery.
Rietdijk J, Tampere M, Pettke A, ..., Puumalainen MR, Carreras-Puigvert J
BMC Biol 19 (1) 156 [2021-08-02; online 2021-08-02]
Category: Biochemistry Category: Drug Discovery Funder: H2020 Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Drug discovery and repurposing of drugs Type: Journal article
PubMed DOI Crossref
Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.
Havervall S, Marking U, Greilert-Norin N, ..., Åberg M, Thålin C
EBioMedicine 70 (-) 103523 [2021-08-00; online 2021-08-12]
Category: Drug Discovery Category: Health Funder: KAW/SciLifeLab National COVID program Research Area: Biobanks for COVID-19 research Research Area: Drug discovery and repurposing of drugs Research Area: High-throughput and high-content serology Research Area: Host cell systems biology and targets Type: Journal article
PubMed DOI Crossref
Topological network based drug repurposing for coronavirus 2019.
Habibi M, Taheri G
PLoS One 16 (7) e0255270 [2021-07-29; online 2021-07-29]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
JAK Inhibitors — More Than Just Glucocorticoids
Stebbing J, Lauschke VM
N Engl J Med 385 (5) 463-465 [2021-07-29; online 2021-07-29]
Category: Drug Discovery Type: Other
PubMed DOI Crossref
Marine Sulfated Polysaccharides as Promising Antiviral Agents: A Comprehensive Report and Modeling Study Focusing on SARS CoV-2.
Salih AEM, Thissera B, Yaseen M, ..., Sayed AM, Rateb ME
Mar Drugs 19 (8) 406 [2021-07-22; online 2021-07-22]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial.
Kosiborod MN, Esterline R, Furtado RHM, ..., Nigro Maia L, Berwanger O
Lancet Diabetes Endocrinol - (-) - [2021-07-21; online 2021-07-21]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease Inhibition.
Ibrahim MAA, Abdelrahman AHM, Atia MAM, ..., El-Seedi HR, Hegazy MF
Mar Drugs 19 (7) - [2021-07-13; online 2021-07-13]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.
Abizanda P, Calbo Mayo JM, Mas Romero M, ..., Lauschke VM, Stebbing J
J Am Geriatr Soc - (-) - [2021-07-08; online 2021-07-08]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.
Liu H, Xin J, Cai S, Jiang X
Elife 10 (-) - [2021-07-06; online 2021-07-06]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19.
Kjellberg A, Douglas J, Pawlik MT, ..., Rodriguez-Wallberg KA, Lindholm P
BMJ Open 11 (7) e046738 [2021-07-05; online 2021-07-05]
Category: Drug Discovery Category: Health Type: Journal article
DOI Crossref
Suggested treatment of serious complications to Covid‐19 vaccination with IdeS, a bacterial antibody‐cleaving enzyme
Kahn F, Shannon O, Björck L
J Thromb Haemost - (-) - [2021-06-24; online 2021-06-24]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study.
Lundberg L, Bygdell M, Stukat von Feilitzen G, ..., Kindblom JM, Leach S
Vaccine - (-) - [2021-06-22; online 2021-06-22]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.
Gossen J, Albani S, Hanke A, ..., Kokh DB, Rossetti G
ACS Pharmacol. Transl. Sci. 4 (3) 1079-1095 [2021-06-11; online 2021-03-16]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients
Fisher J, Mohanty T, Karlsson C, ..., Malmstrom J, Linder A
Molecular & Cellular Proteomics - (-) 100113 [2021-06-00; online 2021-06-00]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
DOI Crossref
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
Noske GD, Nakamura AM, Gawriljuk VO, ..., Oliva G, Godoy AS
Journal of Molecular Biology - (-) 167118 [2021-06-00; online 2021-06-00]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Immunogenicity of a first dose of mRNA- or vector-based SARS-CoV-2 vaccination in dialysis patients: a multicenter prospective observational pilot study.
Lesny P, Anderson M, Cloherty G, ..., Macario F, Haase M
J Nephrol - (-) - [2021-05-29; online 2021-05-29]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.
Miller A, Leach A, Thomas J, ..., Van Montfort R, Rabbitts T
Sci Rep 11 (1) 10617 [2021-05-19; online 2021-05-19]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.
Prats-Uribe A, Sena AG, Lai LYH, ..., Ryan PB, Prieto-Alhambra D
BMJ 373 (-) n1038 [2021-05-11; online 2021-05-11]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
Aspirin and NSAID use and the risk of COVID-19
Drew DA, Guo CG, Lee KA, ..., Steves CJ, Chan AT
medRxiv - (-) - [2021-05-02; online 2021-05-02]
Category: Biochemistry Category: Drug Discovery Category: Health Funder: VR Type: Preprint
PubMed DOI Crossref
A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.
Habibi M, Taheri G, Aghdam R
Sci Rep 11 (1) 9378 [2021-04-30; online 2021-04-30]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.
Axfors C, Schmitt AM, Janiaud P, ..., Ioannidis JPA, Hemkens LG
Nat Commun 12 (1) 2349 [2021-04-15; online 2021-04-15]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
GRAd-COV2, a gorilla adenovirus based candidate vaccine against COVID-19, is safe and immunogenic in young and older adults
Lanini S, Capone S, Antinori A, ..., Folgori A, Ippolito G
medRxiv - (-) - [2021-04-13; online 2021-04-13]
Category: Biochemistry Category: Drug Discovery Type: Preprint
PubMed DOI Crossref
A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated.
Follmann D, Fintzi J, Fay MP, ..., Gilbert PB, Neuzil KM
Ann Intern Med - (-) - [2021-04-13; online 2021-04-13]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.
Ramakrishnan S, Nicolau DV, Langford B, ..., Russell REK, Bafadhel M
Lancet Respir Med - (-) - [2021-04-09; online 2021-04-09]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Gaziano L, Giambartolomei C, Pereira AC, ..., Casas JP, VA Million Veteran Program COVID-19 Science Initiative
Nat Med 27 (4) 668-676 [2021-04-09; online 2021-04-09]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M pro) Inhibitors.
Ibrahim MAA, Abdelrahman AHM, Mohamed TA, ..., Efferth T, Hegazy MF
Molecules 26 (7) - [2021-04-05; online 2021-04-05]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021.
Fabiani M, Ramigni M, Gobbetto V, ..., Pezzotti P, Piovesan C
Euro Surveill 26 (17) - [2021-04-00; online 2021-05-01]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum.
Lehto J, Huguet Ninou A, Chioureas D, Jonkers J, Gustafsson NMS
Cancers (Basel) 13 (6) - [2021-03-22; online 2021-03-22]
Category: Drug Discovery Category: Health Funder: H2020 Type: Journal article
PubMed DOI Crossref
Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus Aloe: An In Silico Study for Drug Development.
Abouelela ME, Assaf HK, Abdelhamid RA, ..., El Zowalaty AE, Abdelkader MSA
Molecules 26 (6) - [2021-03-21; online 2021-03-21]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
A bispecific monomeric nanobody induces SARS-COV-2 spike trimer dimers
Hanke L, Das H, Sheward DJ, ..., Murrell B, McInerney GM
bioRxiv - (-) - [2021-03-21; online 2021-03-21]
Category: Biochemistry Category: Drug Discovery Type: Preprint
PubMed DOI Crossref
COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial.
Welén K, Överby AK, Ahlm C, ..., Gisslén M, Josefsson A
Trials 22 (1) 209 [2021-03-16; online 2021-03-16]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers.
Danlos FX, Grajeda-Iglesias C, Durand S, ..., Fontenay M, Kroemer G
Cell Death Dis 12 (3) 258 [2021-03-11; online 2021-03-11]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19.
Gupta A, Madhavan MV, Poterucha TJ, ..., Wan EY, Parikh SA
Nat Commun 12 (1) 1325 [2021-02-26; online 2021-02-26]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Efficacy and tolerability of bevacizumab in patients with severe Covid-19.
Pang J, Xu F, Aondio G, ..., Chen Y, Cao Y
Nat Commun 12 (1) 814 [2021-02-05; online 2021-02-05]
Category: Biochemistry Category: Drug Discovery Funder: VR Type: Journal article
PubMed DOI Crossref
DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice
Szurgot I, Hanke L, Sheward DJ, ..., McInerney GM, Liljeström P
Sci Rep 11 (1) 3125 [2021-02-04; online 2021-02-04]
Category: Biochemistry Category: Drug Discovery Category: Vaccines Funder: VR Type: Journal article
PubMed DOI Crossref
An analytical study of drug utilization, disease progression, and adverse events among 165 COVID-19 patients.
Sun F, Kou H, Wang S, ..., Zhan S, Cheng H
Ann Transl Med 9 (4) 306 [2021-02-00; online 2021-03-13]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus.
Tomić D, Davidović D, Szasz AM, ..., Šojat Z, Rogina BM
Inform Med Unlocked 23 (-) 100529 [2021-01-30; online 2021-01-30]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
The angiotensin type 2 receptor agonist C21 restores respiratory function in COVID19 - a double-blind, randomized, placebo-controlled Phase 2 trial
Tornling G, Batta R, Porter J, ..., Dalsgaard CJ, Raud J
medRxiv - (-) - [2021-01-28; online 2021-01-28]
Category: Biochemistry Category: Drug Discovery Type: Preprint
PubMed DOI Crossref
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Tian JH, Patel N, Haupt R, ..., Glenn G, Smith G
Nat Commun 12 (1) 372 [2021-01-14; online 2021-01-14]
Category: Biochemistry Category: Drug Discovery Category: Vaccines Type: Journal article
PubMed DOI Crossref
Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial.
Arnardottir H, Pawelzik SC, Öhlund Wistbacka U, ..., Religa D, Bäck M
Front Physiol 11 (-) 624657 [2021-01-11; online 2021-01-11]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
Monteil V, Dyczynski M, Lauschke VM, ..., Penninger JM, Mirazimi A
EMBO Mol Med 13 (1) e13426 [2021-01-11; online 2020-12-14]
Category: Biochemistry Category: Drug Discovery Funder: H2020 Funder: VR Type: Journal article
PubMed DOI Crossref
Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.
Wørzner K, Sheward DJ, Schmidt ST, ..., Christensen D, Pedersen GK
EBioMedicine 63 (-) 103197 [2021-01-00; online 2021-01-07]
Category: Biochemistry Category: Drug Discovery Funder: H2020 Research Area: Data-driven research – models and AI Type: Journal article

Year 2020

PubMed DOI Crossref
Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.
Wong AO, Gurung B, Wong WS, ..., Li RA, Hajjar RJ
J Mol Cell Cardiol 153 (-) 106-110 [2020-12-26; online 2020-12-26]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study.
Lane JCE, Weaver J, Kostka K, ..., Prieto-Alhambra D, OHDSI-COVID-19 consortium
Rheumatology (Oxford) - (-) - [2020-12-25; online 2020-12-25]
Category: Drug Discovery Category: Health Type: Journal article
PubMed DOI Crossref
Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19
Bocci G, Bradfute SB, Ye C, ..., Sklar LA, Oprea TI
ACS Pharmacol. Transl. Sci. 3 (6) 1278-1292 [2020-12-11; online 2020-10-14]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere M, Pettke A, Salata C, ..., Jafari R, Puumalainen MR
Viruses 12 (12) 1423 [2020-12-10; online 2020-12-10]
Category: Biochemistry Category: Drug Discovery Category: Genomics & transcriptomics Category: Proteins Funder: VR Type: Journal article
PubMed DOI Crossref
Modeling of the adsorption of a protein-fragment on kaolinite with potential antiviral activity.
Awad ME, Borrego-Sánchez A, Escamilla-Roa E, Hernández-Laguna A, Sainz-Díaz CI
Appl Clay Sci 199 (-) 105865 [2020-12-01; online 2020-10-14]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.
Friman T, Chernobrovkin A, Martinez Molina D, Arnold L
SLAS Discov - (-) 2472555220973597 [2020-11-18; online 2020-11-18]
Category: Biochemistry Category: Drug Discovery Type: Journal article
DOI Crossref
Local topology, bifurcations and mutation hot-spots in proteins with SARS-CoV-2 spike protein as an example
Peng X, Niemi AJ
bioRxiv - (-) - [2020-11-12; online 2020-11-12]
Category: Biochemistry Category: Drug Discovery Type: Preprint
PubMed DOI Crossref
Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach.
Murugan NA, Kumar S, Jeyakanthan J, Srivastava V
Sci Rep 10 (1) 19125 [2020-11-05; online 2020-11-05]
Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors.
Ibrahim MAA, Abdelrahman AHM, Hussien TA, ..., Efferth T, Hegazy MF
Comput Biol Med 126 (-) 104046 [2020-11-00; online 2020-10-08]
Category: Biochemistry Category: Drug Discovery Type: Journal article
PubMed DOI Crossref
On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.
Sauvat A, Ciccosanti F, Colavita F, ..., Piacentini M, Kroemer G
Cell Death Dis 11 (8) 656 [2020-08-19; online 2020-08-19]
Category: Biochemistry Category: Drug Discovery Funder: H2020 Type: Journal article
PubMed DOI Crossref
Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs.
Neogi U, Hill KJ, Ambikan AT, ..., Sarafianos SG, Singh K
Pathogens 9 (5) - [2020-04-26; online 2020-04-26]
Category: Biochemistry Category: Drug Discovery Funder: VR Type: Journal article
DOI Crossref
Steroid-responsive encephalitis in Covid-19 disease
Pilotto A, Odolini S, Masciocchi S S, ..., Zetterberg H, Padovani A
- - (-) - [2020-04-17; online 2020-04-17]
Category: Biochemistry Category: Drug Discovery Category: Health Type: Preprint
SciLifeLab Data Centre
Publications 9.5.1