Sci Rep

Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA).

Wang M, Kamali-Moghaddam M, Löf L, ..., Landegren U, Zhao H

Sci Rep 14 (1) 21655 [2024-09-17; online 2024-09-17]

Individually tailored exercise in patients with postural orthostatic tachycardia syndrome related to post-COVID-19 condition - a feasibility study.

Svensson A, Svensson-Raskh A, Holmström L, ..., Fedorowski A, Nygren-Bonnier M

Sci Rep 14 (1) 20017 [2024-08-28; online 2024-08-28]

Emergence of SARS-CoV-2 omicron variant JN.1 in Tamil Nadu, India - Clinical characteristics and novel mutations.

Selvavinayagam ST, Sankar S, Yong YK, ..., Shankar EM, Raju S

Sci Rep 14 (1) 17476 [2024-07-30; online 2024-07-30] Open Access

Category: Omicron VoC Funder: VR Type: Journal article

The impact of COVID-19 on microRNA and CD marker expression in AML patients.

Saeed RH, Abdulrahman ZFA, Mohammad DK

Sci Rep 14 (1) 14251 [2024-06-20; online 2024-06-20] Open Access

National prevalence of smoking among adolescents at tobacco tax increase and COVID-19 pandemic in South Korea, 2005-2022.

Hong S, Woo S, Kim S, ..., Lee H, Yon DK

Sci Rep 14 (1) 7823 [2024-04-03; online 2024-04-03] Open Access

Category: Health Category: Public Health Type: Journal article

Plasma neutrophil gelatinase-associated lipocalin independently predicts dialysis need and mortality in critical COVID-19.

Engström J, Koozi H, Didriksson I, ..., Frigyesi A, Spångfors M

Sci Rep 14 (1) 6695 [2024-03-20; online 2024-03-20] Open Access

Category: Health Category: Proteins Type: Journal article

Evidence from 43 countries that disease leaves cultures unchanged in the short-term.

Pasin GL, Szekely A, Eriksson K, ..., di Sorrentino EP, Andrighetto G

Sci Rep 14 (1) 6502 [2024-03-18; online 2024-03-18] Open Access

Category: Social Science & Humanities Funder: KAW/SciLifeLab National COVID program Type: Journal article

Gut microbiota composition is altered in postural orthostatic tachycardia syndrome and post-acute COVID-19 syndrome.

Hamrefors V, Kahn F, Holmqvist M, ..., Fedorowski A, Ohlsson B

Sci Rep 14 (1) 3389 [2024-02-09; online 2024-02-09] Open Access

Category: Health Category: Post-COVID Type: Journal article

DOI Crossref

Assessing the effects of pandemic risk on cooperation and social norms using a before-after Covid-19 comparison in two long-term experiments

Vriens E, Szekely A, Lipari F, ..., Tummolini L, Andrighetto G

Sci Rep 14 (1) - [2024-02-09; online 2024-02-09] Open Access

Category: Social Science & Humanities Funder: VR Type: Journal article

Evidence of COVID-19 fatalities in Swedish neighborhoods from a full population study.

Wixe S, Lobo J, Mellander C, Bettencourt LMA

Sci Rep 14 (1) 2998 [2024-02-06; online 2024-02-06] Open Access

Category: Health Category: Social Science & Humanities Type: Journal article

A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death.

Minnai F, Biscarini F, Esposito M, ..., Renieri A, Colombo F

Sci Rep 14 (1) 3000 [2024-02-06; online 2024-02-06] Open Access

Category: Genomics & transcriptomics Type: Journal article

National prevalence and trends in food labeling awareness, comprehension, usage, and COVID-19 pandemic-related factors in South Korea, 2014-2022.

Choi Y, Kim HJ, Park J, ..., Lim H, Yon DK

Sci Rep 14 (1) 2617 [2024-01-31; online 2024-01-31] Open Access

Category: Other Type: Journal article

Lifestyle and behavioural changes in older adults during the Covid-19 pandemic are associated with subjective cognitive complaints.

Zsuffa JA, Katz S, Koszovacz V, ..., Kivipelto M, Horvath AA

Sci Rep 14 (1) 2502 [2024-01-30; online 2024-01-30] Open Access

Category: Health Category: Social Science & Humanities Type: Journal article

Airborne SARS-CoV2 virus exposure, interpersonal distance, face mask and perceived risk of infection.

Svenson O, Isohanni F, Salo I, Lindholm T

Sci Rep 14 (1) 2285 [2024-01-27; online 2024-01-27] Open Access

Category: Public Health Category: Social Science & Humanities Type: Journal article

Sick leave one year after COVID-19 infection: a nationwide cohort study during the first wave in Sweden.

Abzhandadze T, Westerlind E, Palstam A, Sunnerhagen KS, Persson HC

Sci Rep 14 (1) 572 [2024-01-05; online 2024-01-05] Open Access

Category: Social Science & Humanities Funder: Forte Type: Journal article

Year 2023

Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets.

Fyles M, Vihta K, Sudre CH, ..., Fearon E, House T

Sci Rep 13 (1) 21705 [2023-12-07; online 2023-12-07] Open Access

Category: Health Funder: VR Type: Journal article

Infectivity of exhaled SARS-CoV-2 aerosols is sufficient to transmit covid-19 within minutes.

Alsved M, Nyström K, Thuresson S, ..., Medstrand P, Löndahl J

Sci Rep 13 (1) 21245 [2023-12-01; online 2023-12-01]

Category: Biochemistry Category: Health Category: Public Health Funder: KAW/SciLifeLab National COVID program Funder: VR Type: Journal article

Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and prospective studies.

Castro-Pearson S, Samorodnitsky S, Yang K, ..., Safo SE, Tignanelli CJ

Sci Rep 13 (1) 20315 [2023-11-20; online 2023-11-20]

Category: Proteins Type: Journal article

Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study.

Mahdi A, Zhao A, Fredengren E, ..., Pernow J, Ståhlberg M

Sci Rep 13 (1) 20230 [2023-11-19; online 2023-11-19] Open Access

Category: Post-COVID Funder: Hjärt-Lungfonden Funder: VR Type: Journal article

Category: Health Funder: Hjärt-Lungfonden Funder: KAW/SciLifeLab National COVID program Funder: NordForsk Funder: VR Type: Journal article

Halvorsen P, Hultström M, Hästbacka J, ..., Orwelius L, Lipcsey M

Sci Rep 13 (1) 18035 [2023-10-21; online 2023-10-21]

Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic.

Gajewski P, Błaziak M, Urban S, ..., Ponikowski P, Zymliński R

Sci Rep 13 (1) 17924 [2023-10-20; online 2023-10-20]

Category: Health Category: Public Health Type: Journal article

Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.

van Wijk RC, Mockeliunas L, van den Hoogen G, ..., Diacon AH, Simonsson USH

Sci Rep 13 (1) 16292 [2023-09-28; online 2023-09-28] Open Access

Category: Health Category: Vaccines Type: Journal article

Identification of essential genes associated with SARS-CoV-2 infection as potential drug target candidates with machine learning algorithms.

Taheri G, Habibi M

Sci Rep 13 (1) 15141 [2023-09-13; online 2023-09-13]

Category: Drug Discovery Category: Genomics & transcriptomics Category: Other Type: Journal article

Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19.

Bark L, Larsson I, Wallin E, ..., Rostami E, Hultström M

Sci Rep 13 (1) 13144 [2023-08-12; online 2023-08-12]

Category: Biochemistry Category: Post-COVID Funder: Hjärt-Lungfonden Funder: KAW/SciLifeLab National COVID program Funder: VR Type: Journal article

Individual-level precision diagnosis for coronavirus disease 2019 related severe outcome: an early study in New York.

Huang CC, Xu H

Sci Rep 13 (1) 11317 [2023-07-13; online 2023-07-13]

Post COVID-19 symptoms are common, also among young adults in the general population.

Mogensen I, Ekström S, Hallberg J, ..., Bergström A, Kull I

Sci Rep 13 (1) 11300 [2023-07-12; online 2023-07-12] Open Access

Category: Health Category: Post-COVID Type: Journal article

Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps.

Torinsson Naluai Å, Östensson M, Fowler PC, ..., Harandi AM, Bende M

Sci Rep 13 (1) 6592 [2023-04-21; online 2023-04-21]

Category: Biochemistry Category: Health Type: Journal article

Prevalence of long COVID complaints in persons with and without COVID-19.

Magnusson K, Turkiewicz A, Flottorp SA, Englund M

Sci Rep 13 (1) 6074 [2023-04-13; online 2023-04-13]

Category: Health Category: Post-COVID Type: Journal article

Risk of venous thromboembolism in patients with COVID-19 during 2020; a retrospective cross-sectional study in a Swedish health care system.

Wretborn J, Jörg M, Benjaminsson Nyberg P, Wilhelms DB

Sci Rep 13 (1) 5469 [2023-04-04; online 2023-04-04]

Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.

Kalyoncu S, Yilmaz S, Kuyucu AZ, ..., Ozturk M, Inan M

Sci Rep 13 (1) 5224 [2023-03-30; online 2023-03-30]

Physical and mental health impact of the COVID-19 pandemic at first year in a Spanish adult cohort.

Castellvi Obiols P, Miranda-Mendizabal A, Recoder S, ..., Lloveras-Bernat I, Forero CG

Sci Rep 13 (1) 4547 [2023-03-20; online 2023-03-20]

Year 2022

Self-reported symptom severity, general health, and impairment in post-acute phases of COVID-19: retrospective cohort study of Swedish public employees.

Larsson SB, von Feilitzen GS, Andersson ME, ..., Nilsson S, Sigström R

Sci Rep 12 (1) 19818 [2022-11-17; online 2022-11-17]

Category: Biochemistry Category: Health Category: Post-COVID Type: Journal article

A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome.

Ahlström B, Frithiof R, Larsson I, ..., Lipcsey M, Hultström M

Sci Rep 12 (1) 15703 [2022-09-20; online 2022-09-20] Open Access

Category: Biochemistry Category: Health Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Biobanks for COVID-19 research Type: Journal article

Spatio-temporal predictions of COVID-19 test positivity in Uppsala County, Sweden: a comparative approach.

van Zoest V, Varotsis G, Menzel U, ..., Martinell M, Fall T

Sci Rep 12 (1) 15176 [2022-09-07; online 2022-09-07]

High-dimensional multinomial multiclass severity scoring of COVID-19 pneumonia using CT radiomics features and machine learning algorithms.

Shiri I, Mostafaei S, Haddadi Avval A, ..., Rahmim A, Zaidi H

Sci Rep 12 (1) 14817 [2022-09-01; online 2022-09-01]

Computational models predicting the early development of the COVID-19 pandemic in Sweden: systematic review, data synthesis, and secondary validation of accuracy

Gerlee P, Jöud A, Spreco A, Timpka T

Sci Rep 12 (1) 13256 [2022-08-02; online 2022-08-02]

Immigrant background and socioeconomic status are associated with severe COVID-19 requiring intensive care.

Nordberg P, Jonsson M, Hollenberg J, ..., Hofmann R, Svensson P

Sci Rep 12 (1) 12133 [2022-07-15; online 2022-07-15]

Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study.

Santosa A, Franzén S, Nåtman J, ..., Parmryd I, Nyberg F

Sci Rep 12 (1) 12047 [2022-07-14; online 2022-07-14]

Category: Public Health Category: Vaccines Funder: Hjärt-Lungfonden Topics: Register-based research Type: Journal article

Prevalence of fatigue at one-year follow-up from the Gothenburg recovery and rehabilitation after COVID-19 and intensive care unit study.

Hussain N, Samuelsson CM, Drummond A, Persson CU

Sci Rep 12 (1) 11501 [2022-07-12; online 2022-07-12]

Seroprevalence of SARS-CoV-2 in Sweden, April 26 to May 9, 2021.

Beser J, Galanis I, Enkirch T, ..., Tegmark Wisell K, Bråve A

Sci Rep 12 (1) 10816 [2022-06-25; online 2022-06-25]

Category: Genomics & transcriptomics Category: Health Type: Journal article

Long-COVID in children and adolescents: a systematic review and meta-analyses.

Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, ..., Cuapio A, Villapol S

Sci Rep 12 (1) 9950 [2022-06-23; online 2022-06-23]

Category: Health Category: Post-COVID Type: Journal article

COVID-19 conspiracy ideation is associated with the delusion proneness trait and resistance to update of beliefs.

Acar K, Horntvedt O, Cabrera A, ..., Lebedev AV, Petrovic P

Sci Rep 12 (1) 10352 [2022-06-20; online 2022-06-20]

A prolonged innate systemic immune response in COVID-19.

Ekstedt S, Piersiala K, Petro M, ..., Kumlien Georén S, Cardell LO

Sci Rep 12 (1) 9915 [2022-06-15; online 2022-06-15]

Category: Biochemistry Category: Health Type: Journal article

Olfactory distortions in the general population.

Olofsson JK, Ekesten F, Nordin S

Sci Rep 12 (1) 9776 [2022-06-13; online 2022-06-13]

Epidemic risk perceptions in Italy and Sweden driven by authority responses to COVID-19.

Raffetti E, Mondino E, Di Baldassarre G

Sci Rep 12 (1) 9291 [2022-06-03; online 2022-06-03]

Category: Health Topics: Register-based research Type: Journal article

The association between maternal characteristics and SARS-CoV-2 in pregnancy: a population-based registry study in Sweden and Norway.

Örtqvist AK, Magnus MC, Söderling J, ..., Håberg SE, Stephansson O

Sci Rep 12 (1) 8355 [2022-05-19; online 2022-05-19]

The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use.

Bornscheuer L, Lundin A, Forsell Y, Lavebratt C, Melas PA

Sci Rep 12 (1) 4963 [2022-03-23; online 2022-03-23]

BMI, sex and outcomes in hospitalised patients in western Sweden during the COVID-19 pandemic.

Lindgren M, Toska T, Alex C, ..., Adiels M, Sjöland H

Sci Rep 12 (1) 4918 [2022-03-22; online 2022-03-22]

Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19.

Kasielska-Trojan A, Manning JT, Jabłkowski M, ..., Hirschberg AL, Antoszewski B

Sci Rep 12 (1) 4573 [2022-03-17; online 2022-03-17]

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection.

Sanchez-Burgos L, Gómez-López G, Al-Shahrour F, Fernandez-Capetillo O

Sci Rep 12 (1) 1626 [2022-01-31; online 2022-01-31] Open Access

Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article

Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing hearts.

Vukusic K, Thorsell A, Muslimovic A, ..., Sandstedt J, Hammarsten O

Sci Rep 12 (1) 965 [2022-01-19; online 2022-01-19]

Category: Biochemistry Category: Health Type: Journal article

Year 2021

Predicting regional COVID-19 hospital admissions in Sweden using mobility data.

Gerlee P, Karlsson J, Fritzell I, ..., Jöud A, Lundh T

Sci Rep 11 (1) 24171 [2021-12-17; online 2021-12-17]

Category: Health Category: Other Type: Journal article

Estimating the SARS-CoV-2 infected population fraction and the infection-to-fatality ratio: a data-driven case study based on Swedish time series data.

Wacker A, Jöud A, Bernhardsson B, ..., Gustafsson F, Soltesz K

Sci Rep 11 (1) 23963 [2021-12-14; online 2021-12-14]

Category: Health Category: Other Category: Public Health Type: Journal article

Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK.

Fazel S, Zhang L, Javid B, Brikell I, Chang Z

Sci Rep 11 (1) 23402 [2021-12-14; online 2021-12-14]

Category: Other Category: Public Health Type: Journal article

Lifestyle and mental health 1 year into COVID-19.

Barbieri PN, Giuntella O, Saccardo S, Sadoff S

Sci Rep 11 (1) 23349 [2021-12-02; online 2021-12-02]

Acquired olfactory loss alters functional connectivity and morphology

DOI Crossref

Iravani B, Peter MG, Arshamian A, ..., Kitzler HH, Lundström JN

Sci Rep 11 (1) - [2021-12-00; online 2021-08-12]

Category: Biochemistry Category: Health Funder: VR Type: Preprint

DOI Crossref

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Lopez-Leon S, Wegman-Ostrosky T, Perelman C, ..., Cuapio A, Villapol S

Sci Rep 11 (1) - [2021-12-00; online 2021-08-09]

Category: Health Type: Preprint Type: Review

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome.

Masood KI, Yameen M, Ashraf J, ..., E Rottenberg M, Hasan Z

Sci Rep 11 (1) 22958 [2021-11-25; online 2021-11-25]

Category: Biochemistry Category: Health Type: Journal article

Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19.

Rivero-García I, Castresana-Aguirre M, Guglielmo L, Guala D, Sonnhammer ELL

Sci Rep 11 (1) 20687 [2021-10-19; online 2021-10-19]

Category: Biochemistry Category: Drug Discovery Category: Health Type: Journal article

Comparing the responses of the UK, Sweden and Denmark to COVID-19 using counterfactual modelling.

Mishra S, Scott JA, Laydon DJ, ..., Ferguson NM, Bhatt S

Sci Rep 11 (1) 16342 [2021-08-11; online 2021-08-11]

Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients.

Huckriede J, Anderberg SB, Morales A, ..., Frithiof R, Nicolaes GAF

Sci Rep 11 (1) 15701 [2021-08-03; online 2021-08-03] Open Access

Category: Health Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Biobanks for COVID-19 research Type: Journal article

Publisher Correction: A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.

Habibi M, Taheri G, Aghdam R

Sci Rep 11 (1) 15550 [2021-07-26; online 2021-07-26]

Type: Other

An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.

Razzaq M, Iglesias MJ, Ibrahim-Kosta M, ..., Morange P, Trégouët D

Sci Rep 11 (1) 14015 [2021-07-07; online 2021-07-07] Open Access

Category: Biochemistry Category: Health Type: Journal article

Mobility restrictions were associated with reductions in COVID-19 incidence early in the pandemic: evidence from a real-time evaluation in 34 countries.

Oh J, Lee HY, Khuong QL, ..., McKee M, Gostin LO

Sci Rep 11 (1) 13717 [2021-07-02; online 2021-07-02]

Category: Other Type: Journal article

A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce.

Carter N, Clausen M, Halpin RA, ..., Wise D, Fidock M

Sci Rep 11 (1) 12676 [2021-06-16; online 2021-06-16] Open Access

Category: Biochemistry Type: Journal article

A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.

Miller A, Leach A, Thomas J, ..., Van Montfort R, Rabbitts T

Sci Rep 11 (1) 10617 [2021-05-19; online 2021-05-19]

Category: Biochemistry Category: Drug Discovery Type: Journal article

A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing.

Habibi M, Taheri G, Aghdam R

Sci Rep 11 (1) 9378 [2021-04-30; online 2021-04-30]

Category: Drug Discovery Type: Journal article

OxCOVID19 Database, a multimodal data repository for better understanding the global impact of COVID-19

Mahdi A, Błaszczyk P, Dłotko P, ..., Hogan B, Tarassenko L

Sci Rep 11 (1) - [2021-04-29; online 2021-04-29]

Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers.

Lagerqvist N, Maleki KT, Verner-Carlsson J, ..., Nilsson C, Klingström J

Sci Rep 11 (1) 7614 [2021-04-07; online 2021-04-07] Open Access

Category: Genomics & transcriptomics Category: Other Funder: VR Type: Journal article

The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients.

Järhult JD, Hultström M, Bergqvist A, Frithiof R, Lipcsey M

Sci Rep 11 (1) 7163 [2021-03-30; online 2021-03-30] Open Access

Category: Health Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Biobanks for COVID-19 research Type: Journal article

Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts.

Molteni E, Astley CM, Ma W, ..., Chan AT, Modat M

Sci Rep 11 (1) 6928 [2021-03-25; online 2021-03-25] Open Access

Category: Public Health Funder: Hjärt-Lungfonden Funder: VR Type: Journal article

Proteomic blood profiling in mild, severe and critical COVID-19 patients.

Patel H, Ashton NJ, Dobson RJB, ..., Gisslen M, Zetterberg H

Sci Rep 11 (1) 6357 [2021-03-18; online 2021-03-18] Open Access

Category: Health Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Biobanks for COVID-19 research Research Area: Biomarkers and systems immunology Type: Journal article

Antibodies to SARS-CoV-2 and risk of past or future sick leave.

Dillner J, Elfström KM, Blomqvist J, ..., Mühr LSA, Conneryd Lundgren K

Sci Rep 11 (1) 5160 [2021-03-04; online 2021-03-04] Open Access

Category: Health Category: Proteins Funder: KAW/SciLifeLab National COVID program Research Area: High-throughput and high-content serology Type: Journal article

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice

Szurgot I, Hanke L, Sheward DJ, ..., McInerney GM, Liljeström P

Sci Rep 11 (1) 3125 [2021-02-04; online 2021-02-04] Open Access

Category: Biochemistry Category: Drug Discovery Category: Vaccines Funder: VR Type: Journal article

Detection of SARS-CoV-2 using non-commercial RT-LAMP regents and raw samples.

Alekseenko A, Barrett D, Pareja-Sanchez Y, ..., Yin X, Pelechano V

Sci Rep 11 (1) 1820 [2021-01-21; online 2020-08-24] Open Access

Category: Other Funder: KAW/SciLifeLab National COVID program Funder: VR Research Area: Diagnostics for virus Research Area: Viral sequence evolution Type: Journal article

Year 2020

Long-distance airborne dispersal of SARS-CoV-2 in COVID-19 wards.

Nissen K, Krambrich J, Akaberi D, ..., Svensson L, Salaneck E

Sci Rep 10 (1) 19589 [2020-11-11; online 2020-11-11]