Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

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Tampere M, Pettke A, Salata C, Wallner O, Koolmeister T, Cazares-Körner A, Visnes T, Hesselman MC, Kunold E, Wiita E, Kalderén C, Lightowler M, Jemth AS, Lehtiö J, Rosenquist Å, Warpman-Berglund U, Helleday T, Mirazimi A, Jafari R, Puumalainen MR

Viruses 12 (12) 1423 [2020-12-10; online 2020-12-10]

Category: Biochemistry

Category: Drug Discovery

Category: Genomics & transcriptomics

Category: Proteins

Funder: VR

Type: Journal article

DOI 10.3390/v12121423

Crossref 10.3390/v12121423

Antiviral screening; Dose-response treatment of TH6744 and TH3289; List of proteins from 2D-TPP analysis in U87 cells (FDR); List of proteins from 2D-TPP analysis in U87 cells (Fold-change); Uniprot annotation of overlapping TPP-TR and 2D-TPP hits
Thermal Proteome Profiling dataset from Hazara virus infected SW13 cells
Raw mass spectrometry data were deposited in the ProteomeXchange Consortium (accession: PXD021494)