Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.

Yang P, Ye X, Liu M, Yang J, Feng X, Li Y, Zhang K, Liang H, Yi Y, Wang L, Liu Y, Yang X, Shi Z, Feng L, Chen L, Xue Y, Pan-Hammarström Q, Wang H, Zhao Y

Adv Healthc Mater 12 (24) e2300673 [2023-09-00; online 2023-05-14]

The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.

Category: Proteins

Type: Journal article

PubMed 37139567

DOI 10.1002/adhm.202300673

Crossref 10.1002/adhm.202300673

Publications 9.5.0