No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19.

Petrazzuolo A, Le Naour J, Vacchelli E, Gaussem P, Ellouze S, Jourdi G, Solary E, Fontenay M, Smadja DM, Kroemer G

Oncoimmunology 9 (1) 1857112 [2020-12-08; online 2020-12-08]

Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells. A single nucleotide polymorphism, rs867228 (allelic frequency 19-20%), in the gene coding for FPR1 accelerates the manifestation of multiple carcinomas, likely due to reduced anticancer immunosurveillance secondary to a defect in antigen presentation by dendritic cells. Another polymorphism in FPR1, rs5030880 (allelic frequency 12-13%), has been involved in the resistance to plague, correlating with the fact that FPR1 is the receptor for Yersinia pestis. Driven by the reported preclinical effects of FPR1 on lung inflammation and fibrosis, we investigated whether rs867228 or rs5030880 would affect the severity of coronavirus disease-19 (COVID-19). Data obtained on patients from two different hospitals in Paris refute the hypothesis that rs867228 or rs5030880 would affect the severity of COVID-19.

Category: Genomics & transcriptomics

Category: Health

Type: Journal article

PubMed 33344044

DOI 10.1080/2162402X.2020.1857112

Crossref 10.1080/2162402X.2020.1857112

pii: 1857112
pmc: PMC7734042
Allelic frequencies of FPR1 SNPs and characteristics of patient population from Hôpital Cochin and Hôpital Européen George Pompidou

Publications 9.5.0