Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms
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Cunningham JL, Virhammar J, Rönnberg B, Castro Dopico X, Kolstad L, Albinsson B, Kumlien E, Nääs A, Klang A, Westman G, Zetterberg H, Frithiof R, Lundkvist Å, Karlsson Hedestam GB, Rostami E
The Journal of Infectious Diseases - (-) -
[2021-03-21; online 2021-03-21]
Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
Funder: KAW/SciLifeLab National COVID program
Research Area: High-throughput and high-content serology
PubMed 33744954
DOI 10.1093/infdis/jiab153
Crossref 10.1093/infdis/jiab153
pii: 6179304
pmc: PMC8083780